The major active component of the Verebey Joint Support is NIACIN. NIACIN AND NIACINAMIDE are precursors of the biochemical co-factors NAD+ and NADH. (NAD = Nicotinamide adenine dinucleotide). These biochemical co-factors are involved in a large number of critical biochemical reactions. They function in all living cells in the body.
NIACIN is converted in the body to NIACINAMIDE which is further converted into NAD+ and NADH .These critical electron transferor co-factors are involved in energy, lipid, and protein synthesis and catabolism. They are involved in the overall metabolic activity of the body.
NIACIN and NIACINAMIDE are highly water soluble and rapidly excreted from the body. That is why the urine appears more yellow after taking the Verebey Joint Support tablet. Yet high bio-availability is necessary for youthful cellular and tissue functions. Dr. Ying’s known publication suggests that DEFICIENCY of NAD+ and NADH Cofactors in the body are responsible for aging and age related diseases. (Ying W, NAD+ and NADH in cellular functions and cell death, 2006, Frontiers in Bioscience, 11:3129-3148)
The exact mechanism directly showing niacin’s ability reducing inflammation related pain and supporting rebuilding joints is not known. However, clinical observations of increased joint flexibility and specific measurements of blood erythrocyte sedimentation rate (ESR) improvements prove niacinamide’s effectiveness in the treatment of joint diseases.
NAD+ and NADH in cellular functions and cell death
Dr. Ying W., Department of Neurology, University of California, San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121 USA
Increasing evidence has indicated that NAD+ and NADH play critical roles not only in energy metabolism, but also in cell death and various cellular functions including regulation of calcium homeostasis and gene expression. It has also been indicated that NAD+ and NADH are mediators of multiple major biological processes including aging.
NAD+ and NADH produce the biological effects by regulating numerous NAD+/NADH-dependent enzymes, including dehydrogenases, poly(ADP-ribose) polymerases, Sir2 family proteins (sirtuins), mono(ADP-ribosyl)transferases, and ADP-ribosyl cyclases.
Of particular interest, NAD+-dependent generation of ADP-ribose, cyclic ADP-ribose and O-acetyl-ADP-ribose can mediate calcium homeostasis by affecting TRPM2 receptors and ryanodine receptors; and sirtuins and PARPs appear to play key roles in aging, cell death and a variety of cellular functions. It has also been indicated that NADH and NAD+ can be transported across plasma membranes of cells, and that extracellular NAD+ may be a new signaling molecule.
Our latest studies have shown that intranasal NAD+ administration can profoundly decrease ischemic brain damage. These new pieces of information have fundamentally changed our understanding about NAD+ and NADH, suggesting novel paradigms about the metabolism and biological activities of NAD+ and NADH. Based on this information, it is tempted to hypothesize that NAD+ and NADH, together with ATP and Ca2+, may be four most fundamental components in life, which can significantly affect nearly all major biological processes.
Future studies on NAD+ and NADH may not only elucidate some fundamental mysteries in biology, but also provide novel insights for interfering aging and many disease processes.
New Study On Paralysis Will Focus On Vitamin B3 Precursor
Weill Cornell Medical College has received a $2.5 million grant from the New York State Spinal Cord Injury Research Board to investigate the impact of a naturally-occurring substance in helping prevent paralysis following an injury.
The research will focus on a vitamin B3 precursor as scientists believe that increasing the levels of the compound that converts to the active form of vitamin B3 (called NAD+) can be useful in preventing permanent nerve damage.
“Our study is aimed at synthesizing a molecule that, when given soon after injury, may augment the body’s production of NAD+ and rescue these cells before they are stressed beyond recovery,” says Dr. Samie Jaffrey, associate professor of pharmacology at Weill Cornell Medical College.
The theory behind the upcoming study is based on the fact that vitamin B3 plays a key role in cells by activating proteins called sirtuins that help the cells survive under stress. Sirtuins, which can be activated by compounds like resveratrol—found in large concentrations in the skin of grapes used to make red wine—have been shown to possess anti-aging and healing properties.
Those interested in maintaining muscle health may also turn to nutritional supplements containing B vitamins.
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